Toremifene: Dosage, Mechanism Onset of Action, Half-Life
Ten patients on anticonvulsants (phenobarbital, clonazepam, phenytoin, and carbamazepine) showed a twofold increase in clearance and a decrease in the elimination half-life of toremifene. In a study of 20 healthy subjects, 2 mg midazolam once daily (days 6 and 18) coadministered with toremifene as a 480 mg loading dose followed by 80 mg once daily for 16 days. Following coadministration on days 6 and 18 relevant increases in midazolam and α-hydroxymidazolam Cmax and AUC were not observed.
- In multicentre comparative trials, objective responses (complete and partial) occurred in 20 to 29% of patients treated with toremifene (60 to 240 mg/day) and in 19 to 37.5% of tamoxifen (20 or 40 mg/day) recipients.
- The cause of the serum enzyme elevations during toremifene therapy is unknown, but they may represent fatty liver disease induced by the estrogen receptor modulation.
- This page contains brief information about toremifene and a collection of links to more information about the use of this drug, research results, and ongoing clinical trials.
- Unlike tamoxifen, toremifene has not been approved as a means of prevention of de novo breast cancer in high risk patients or for prevention of recurrence of breast cancer.
Try to pace yourself and plan your day so you have time to rest between activities. You may get some of the side effects we mention, but you are unlikely to get all of them. And you may have some side effects, including rarer ones, that we have not listed here. Your doctor will talk to you about this treatment and its possible side effects before you agree (consent) to have treatment.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies. This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
1 Drugs that Decrease Renal Calcium Excretion
Toremifene is used in postmenopausal women to treat breast cancer. It is usually used to treat cancer that needs estrogen, a hormone, in order to grow (estrogen-receptor positive). Toremifene is a nonsteroidal antiestrogen that blocks the effects of estrogen in the breast tissue, thereby slowing or stopping the growth of cancer. Toremifene is used to treat metastatic breast cancer (cancer that has spread) that is hormone-receptor positive in women who have already stopped menstruating (postmenopausal). Sometimes it is not safe to use certain medications at the same time.
1 Prolongation of the QT Interval
Incidence (%) of certain tumours in Sprague-Dawley rats exposed to Buy Letrozol 2.5 mg USA citrate. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Do not take more or less of it or take it more often than prescribed by your doctor.
Why is this medication prescribed?
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this drug with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor. The dose of this medicine will be different for different patients. Follow your doctor’s orders or the directions on the label.
